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LTB4R2 / BLT2
leukotriene B4 receptor 2
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
| Gene Name: | leukotriene B4 receptor 2 |
| Family/Subfamily: | GPCR , Chemoattractant |
| Synonyms: | LTB4R2, BLT2, BLTR2, Blt-2, BLT2R, JULF2, LTB4-R2, Hblt2, KPG_004, Leukotriene B4 receptor 2, Leukotriene B4 receptor BLT2, LTB4 receptor JULF2, LTB4-R 2 |
| Target Sequences: | NM_019839 NP_062813.2 Q9NPC1 |
Publications (3)
1
Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Bck M, Bu DX, Brnstrm R, Sheikine Y, Yan ZQ, Hansson GK. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:17501-6. (IHC-Fr; Human)
[PubMed:16293697]
[PMC:PMC1297663]
Related Antibodies: LS-A2099.
2
Leukotriene B4 receptor-2 promotes invasiveness and metastasis of ovarian cancer cells through signal transducer and activator of transcription 3 (STAT3)-dependent up-regulation of matrix metalloproteinase 2. Seo JM, Park S, Kim JH. The Journal of biological chemistry. 2012 Apr;287:13840-9. [Full Text Article]
[PubMed:22396544]
[PMC:PMC3340142]
Related Antibodies: LS-A2099.
3
BLT2 promotes the invasion and metastasis of aggressive bladder cancer cells through a reactive oxygen species-linked pathway. Kim EY, Seo JM, Kim C, Lee JE, Lee KM, Kim JH. Free radical biology & medicine. 2010 Sep;49:1072-81. [Full Text Article]
[PubMed:20600831]
Related Antibodies: LS-A2097.
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Proteins
(4)
Type
Over-Expression Lysate
(4)
Target
LTB4R2 / BLT2
(4)
Publications
No
(4)
Tag
Myc-DDK (Flag)
(4)
Species
Human
(2)
Source
293T Cells
(2)
HEK 293 Cells
(2)
293T Cells
Myc-DDK (Flag)
37.8 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
37.8 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
37.8 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
37.8 kDa
100 µg/$494
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