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E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.
Gene Name: | leucine rich repeat and sterile alpha motif containing 1 |
Synonyms: | LRSAM1, CMT2P, HTAL, Tsg101-associated ligase, RIFLE, TAL |
Target Sequences: | NM_001005373 NP_001005373.1 Q6UWE0 |
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