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Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore By similarity. Mediates the import of the antibiotic blasticidin-S into cell (PubMed:24782309).
Gene Name: | Leucine Rich Repeat Containing 8 Family, Member D |
Synonyms: | LRRC8D, LRRC5 |
Target Sequences: | NM_018103 NP_060573.2 Q7L1W4 |
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