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LRP6

low density lipoprotein receptor-related protein 6

Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) is a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. LRP6 functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade LRP6 plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. LRP6 undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

Gene Name: low density lipoprotein receptor-related protein 6
Synonyms: LRP6, ADCAD2, LRP-6
Target Sequences: NM_002336 NP_002327.2 O75581

Publications (2)

1
LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Liu CC, Prior J, Piwnica-Worms D, Bu G. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:5136-41. [PubMed:20194742] [PMC:PMC2841938] Related Antibodies: LS-C100405.
2
Systems Genetics Analysis of a Recombinant Inbred Mouse Cell Culture Panel Reveals Wnt Pathway Member Lrp6 as a Regulator of Adult Hippocampal Precursor Cell Proliferation. Kannan S, Nicola Z, Overall RW, Ichwan M, Ramírez-Rodríguez G, N Grzyb A, Patone G, Saar K, Hübner N, Kempermann G. Stem cells (Dayton, Ohio). 2016 March;34:674-84. (Human) [Full Text Article] [PubMed:26840599]

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LRP6 Protein - Recombinant Low Density Lipoprotein Receptor Related Protein 6 By SDS-PAGE
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E. coli
His, N-Terminal
30.4 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
LRP6 Protein - Purified recombinant protein LRP6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
178.4 kDa
20 µg/$1,107
LRP6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
180.44 kDa
20 µg/$215
LRP6 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
180.44 kDa
100 µg/$710
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).