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LRP1 / CD91

low density lipoprotein receptor-related protein 1

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

Gene Name: low density lipoprotein receptor-related protein 1
Synonyms: LRP1, Apolipoprotein E receptor, CD91 antigen, CD91, A2MR, IGFBP3R, Alpha-2-macroglobulin receptor, TGFBR5, Type V tgf-beta receptor, APOER, APR, LRP, LRP-1, LRP-85, LRP-515, LRPICD
Target Sequences: NM_002332 NP_002323.2 Q07954

Publications (2)

1
ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment. Chi-Lam Au-Yeung, Tsz-Lun Yeung, Abhinav Achreja, Hongyun Zhao, Kay-Pong Yip, Suet-Ying Kwan, Michaela Onstad, Jianting Sheng, Ying Zhu, Dodge L Baluya, Ngai-Na Co, Angela Rynne-Vidal, Rosemarie Schmandt, Matthew L Anderson, Karen H Lu, Stephen T C Wong, Deepak Nagrath, Samuel C Mok. Nature communications. 2020 July;11:3546. [Full Text Article] [PubMed:32669559] [PMC:PMC7363861] Related Antibodies: LS-B2675.
2
Changes of blood-brain-barrier function and transfer of amyloid beta in rats with collagen-induced arthritis. Po-Hsuan Lai, Ting-Hsuan Wang, Nai-You Zhang, Kuo-Chen Wu, Chung-Chen Jane Yao, Chun-Jung Lin. Journal of neuroinflammation. 2021 Jan;18:35. [Full Text Article] [PubMed:33516259] [PMC:PMC7847579]

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Products
Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
LRP1 / CD91 (6)
No (6)
GST (1)
His (1)
His, N-Terminal (1)
His-GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
Mouse (2)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
LRP1 / CD91 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
504.61 kDa
20 µg/$215
LRP1 / CD91 Protein - Recombinant Low Density Lipoprotein Receptor Related Protein 1 By SDS-PAGE
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E. coli
His, N-Terminal
33.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
LRP1 / CD91 Protein - Recombinant Low Density Lipoprotein Receptor Related Protein 1 By SDS-PAGE
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E. coli
His
13.0 kDa
10 µg/$265; 50 µg/$347; 100 µg/$545; 200 µg/$682; 1 mg/$1,690; 500 µg/$1,270; 5 mg/$2,637; 2 mg/$1,866
LRP1 / CD91 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
504.61 kDa
100 µg/$710
LRP1 / CD91 Protein - Recombinant Low Density Lipoprotein Receptor Related Protein 1 By SDS-PAGE
Select
E. coli
His-GST, N-terminus
42.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
LRP1 / CD91 Protein - 12.5% SDS-PAGE of human LRP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
58 kDa
10 µg/$479; 25 µg/$670
Viewing 1-6 of 6 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).