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LPP3 / PPAP2B is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells.
Gene Name: | phosphatidic acid phosphatase type 2B |
Synonyms: | PPAP2B, Dri42, PAP2 beta, PAP2-beta, PAP2B, VCIP, PAP-2b, LPP3 |
Target Sequences: | NM_003713 NP_003704.3 O14495 |
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