LOXL2

lysyl oxidase-like 2

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

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Products

Proteins (11)

Type

Over-Expression Lysate (2)

Recombinant (9)

Target

LOXL2 (11)

Application

SDS-PAGE (1)

Publications

No (11)

Tag

GST, N-terminus (1)

His (6)

His, N-Terminal (1)

His,C-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Mouse (4)

Rat (2)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

Low Endotoxin Level

Low endotoxin level (1)

Biologically Active

Biologically active (1)

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Mouse LOXL2 Protein (Recombinant His) (aa53-160) - LS-G15679

Source:

E. coli

Tag:

His

Molecular Weight:

13.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209

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Mouse LOXL2 Protein (Recombinant His,C-terminus) (Met1-Gln776) - LS-G49203

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant mouse Loxl2 consists 762 amino acids and predicts a molecular mass of 85.9 kDa.

Price:

100 µg/$480

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Human LOXL2 Protein (Recombinant His) (aa544-751) - LS-G15680

Source:

E. coli

Tag:

His

Molecular Weight:

25.6 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Human LOXL2 Protein (Recombinant His, N-Terminal) (aa323-427) - LS-G15677

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

12.8 kDa

Price:

10 µg/$291; 50 µg/$502; 200 µg/$1,002; 1 mg/$2,144; 5 mg/$3,501; 2 mg/$2,334

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Mouse LOXL2 Protein (Recombinant His) (aa26-776) - LS-G20934

Source:

E. coli

Tag:

His

Molecular Weight:

88.48 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Mouse LOXL2 Protein (Recombinant His) (aa26-776) - LS-G23012

Source:

Yeast

Tag:

His

Molecular Weight:

86.43 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human LOXL2 Protein (Recombinant GST, N-terminus) (aa675-773) - LS-G59137

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Rat LOXL2 Protein (Recombinant His) (aa553-761) - LS-G15681

Source:

E. coli

Tag:

His

Molecular Weight:

25.8 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Rat LOXL2 Protein (Recombinant His) (aa434-546) - LS-G15678

Source:

E. coli

Tag:

His

Molecular Weight:

13.9 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human LOXL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88688

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.71 kDa

Price:

20 µg/$150

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LOXL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99729

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86.71 kDa

Price:

100 µg/$494

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