LOXL2

lysyl oxidase-like 2

Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

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Products

ELISA Kits (11)

Type

Competitive EIA (1)

Custom (4)

Sandwich (6)

Target

LOXL2 (11)

Reactivity

Human (5)

Mouse (2)

Rat (2)

Chicken (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (10)

Publications

No (11)

Sample Type

Cell Culture Supernatants (4)

Cell Lysates (3)

Plasma (6)

Serum (6)

Tissue Homogenates (5)

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Human LOXL2 (Sandwich ELISA) ELISA Kit - LS-F7178

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

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Mouse LOXL2 (Sandwich ELISA) ELISA Kit - LS-F17515

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$669

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Mouse LOXL2 (Sandwich ELISA) ELISA Kit - LS-F7478

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$748

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Rat LOXL2 (Sandwich ELISA) ELISA Kit - LS-F8037

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Human LOXL2 (Sandwich ELISA) ELISA Kit - LS-F39947

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum

Price:

1 Plate/$699

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Rat LOXL2 (Custom ELISA) ELISA Kit - LS-F17516

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Bovine LOXL2 (Custom ELISA) ELISA Kit - LS-F17517

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Chicken LOXL2 (Custom ELISA) ELISA Kit - LS-F17518

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human LOXL2 (Sandwich ELISA) ELISA Kit - LS-F31663

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

156 - 10000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$624

Select

Human LOXL2 (Custom ELISA) ELISA Kit - LS-F50635

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$559

Select

Human LOXL2 (Competitive EIA) ELISA Kit - LS-F67329

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

37.5 - 2400 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$579

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