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LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Name: | LIM domain only 2 (rhombotin-like 1) |
Synonyms: | LMO2, LIM domain only protein 2, LMO-2, RHOM2, RBTNL1, Rhombotin 2, Rhombotin-like 1, Cysteine-rich protein TTG-2, RBTN2, Rhombotin-2, T-cell translocation gene 2, T-cell translocation protein 2, TTG2 |
Target Sequences: | NM_005574 NP_005565.2 P25791 |
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