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This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described.
Gene Name: | LIM domain only 1 (rhombotin 1) |
Synonyms: | LMO1, Cysteine-rich protein TTG-1, LIM domain only protein 1, LMO-1, RBTN1, RHOM1, Rhombotin-1, T-cell translocation protein 1, T-cell translocation gene 1, TTG1 |
Target Sequences: | NM_002315 NP_002306.1 P25800 |
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