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The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Name: | lethal giant larvae homolog 2 (Drosophila) |
Synonyms: | LLGL2, Human giant larvae homolog, HGL, LGL2 |
Target Sequences: | NM_004524 NP_004515.2 Q6P1M3 |
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