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Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Gene Name: | lipase A, lysosomal acid, cholesterol esterase |
Synonyms: | LIPA, Cholesterol ester hydrolase, Cholesteryl esterase, LAL, Lysosomal acid lipase, Lipase A, Sterol esterase, CESD |
Target Sequences: | NM_000235 NP_000226.2 P38571 |
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