LIMK1 / LIMK

LIM domain kinase 1

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

LIMK1 / LIMK (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human LIMK1 / LIMK Protein (Recombinant GST) (Full Length) - LS-G29200

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

96.8 kDa

Price:

2 µg/$439

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Human LIMK1 / LIMK Protein (Recombinant GST, N-terminus) (aa548-647) - LS-G59123

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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LIMK1 / LIMK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99723

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.4 kDa

Price:

100 µg/$710

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Human LIMK1 / LIMK Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66175

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.4 kDa

Price:

20 µg/$1,107

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Human LIMK1 / LIMK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77110

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.4 kDa

Price:

20 µg/$215

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