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LILRA3 is a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region.
Gene Name: | Leukocyte Immunoglobulin-like Receptor, Subfamily A (WITHOUT TM DOMAIN), Member 3 |
Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
Synonyms: | LILRA3, E3, HM43, ILT-6, ILT6, LIR-4, LIR4, HM31, CD85E, CD85e antigen |
Target Sequences: | NM_006865 |
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