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LIR6 / LILRA1 is an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Name: | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 |
Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
Synonyms: | LILRA1, CD85I, CD85i antigen, LIR-6, LIR6 |
Target Sequences: | NM_006863 NP_006854.1 O75019 |
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