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LHX8 is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants.
Gene Name: | LIM homeobox 8 |
Synonyms: | LHX8, LIM homeobox protein 8, LIM-homeodomain protein Lhx8, LIM/homeobox protein Lhx8, LHX7, LIM homeobox 8 |
Target Sequences: | Q68G74 Q68G74 |
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