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LGALS3 / Galectin 3
lectin, galactoside-binding, soluble, 3
LGALS3 / Galectin 3 is a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.
| Gene Name: | lectin, galactoside-binding, soluble, 3 |
| Synonyms: | LGALS3, 35 kd lectin, 35 kDa lectin, CBP35, GAL3, Galactoside-binding protein, GALIG, IgE-binding protein, Laminin-binding protein, Gal-3, GALBP, MAC-2, Mac-2 antigen, L31, MAC2, CBP 35, Galactose-specific lectin 3, Galectin-3, L-31, Lectin L-29 |
| Target Sequences: | NM_002306 NP_002297.2 P17931 |
Publications (8)
1
Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes. Berger A, Mnk C, Schweizer M, Cichutek K, Schle S, Flory E. The Journal of biological chemistry. 2010 285:12248-54.
[PubMed:20178977]
[PMC:PMC2852964]
2
AlphaB-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells. Gangalum RK, Atanasov IC, Zhou ZH, Bhat SP. The Journal of biological chemistry. 2011 286:3261-9.
[PubMed:21097504]
[PMC:PMC3030331]
3
FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. Kuang SQ, Medina-Martinez O, Guo DC, Gong L, Regalado ES, Reynolds CL, Boileau C, Jondeau G, Prakash SK, Kwartler CS, Zhu LY, Peters AM, Duan XY, Bamshad MJ, Shendure J, Nickerson DA, Santos-Cortez RL, Dong X, Leal SM, Majesky MW, Swindell EC, Jamrich M, Milewicz DM. The Journal of clinical investigation. 2016 126:948-61. (WB; Mouse)
[Full Text Article]
[PubMed:26854927]
[PMC:PMC4767350]
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LGALS3 / Galectin 3
(250)
Reactivity
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(183)
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(67)
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(7)
LGALS3 / Galectin 3 Mouse anti-Human Monoclonal (aa151-251) (Gal397) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
250 µg/$545
Cancer Pathology
Cancer
LGALS3 / Galectin 3 Rabbit anti-Human Polyclonal (aa141-190) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$460
LGALS3 / Galectin 3 Goat anti-Mouse Polyclonal (aa155-168) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
Cancer Pathology
Cancer
LGALS3 / Galectin 3 Rabbit anti-Human Polyclonal (aa38-87) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
LGALS3 / Galectin 3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$396
LGALS3 / Galectin 3 Mouse anti-Human Monoclonal (52C1) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
LGALS3 / Galectin 3 Mouse anti-Human Monoclonal (1G8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
LGALS3 / Galectin 3 Mouse anti-Human Monoclonal (B2C10) Antibody
Mouse, Human
Flo, Func, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$589
LGALS3 / Galectin 3 Rabbit anti-Mouse Polyclonal (aa153-264) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Sandwich
96-Well Microplate
Mouse
8.19 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$635
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
26.0 kDa
10 µg/$268; 50 µg/$349
Sandwich
96-Well Microplate
Rat
3.28 - 800 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Microplate
Human
0.819 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
E. coli
His
28.4 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
LGALS3 / Galectin 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$460
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
LGALS3 / Galectin 3 Mouse anti-Human Monoclonal (aa1-58) (A3A12) Antibody
Mouse, Rat, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µg/$866
LGALS3 / Galectin 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
LGALS3 / Galectin 3 Rabbit anti-Mouse Polyclonal (aa2-264) Antibody
Rat, Human
ICC, IHC-P, IP, WB
Unconjugated
50 µl/$460
LGALS3 / Galectin 3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, WB
Unconjugated
200 µl/$468
LGALS3 / Galectin 3 Rabbit anti-Human Polyclonal (aa163-191) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
LGALS3 / Galectin 3 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µl/$412
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