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Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
Gene Name: | leptin receptor overlapping transcript |
Synonyms: | LEPROT, OB-RGRP, OBRGRP, OBR, Vps55, OB-R gene-related protein |
Target Sequences: | NM_017526 NP_059996.1 O15243 |
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