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LECT1 / Chondromodulin-I

leukocyte cell derived chemotaxin 1

LECT1 / Chondromodulin-I is a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: leukocyte cell derived chemotaxin 1
Synonyms: LECT1, BRICHOS domain containing 3, CHM-I, CHMI, Chondromodulin I, Chondromodulin-I, Chondromodulin-1, MYETS1, BRICD3, CHM1, Chondromodulin
Target Sequences: NM_007015 NP_008946.1 O75829

Publications (1)

1
TGF-ß mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease. Munjal C, Opoka AM, Osinska H, James JF, Bressan GM, Hinton RB. Disease models & mechanisms. 2014 7:987-96. (IHC; Mouse) [Full Text Article] [PubMed:25056700] [PMC:PMC4107327] Related Antibodies: LS-C80668.

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Products
Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
LECT1 / Chondromodulin-I (10)
SDS-PAGE (1)
No (10)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
Fc (1)
GST (1)
His (2)
His-T7 (1)
Human IgG1 Fc, N-terminus (1)
Myc-DDK (Flag) (2)
Human (9)
293T Cells (1)
E. coli (5)
HEK 293 Cells (2)
Human Cells (1)
Wheat Germ Extract (1)
Purified (5)
Low endotoxin level (2)
LECT1 / Chondromodulin-I Protein
Select
HEK 293 Cells
Human IgG1 Fc, N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human LECT1 consists 379 amino acids and predicts a molecular mass of 42.1 kDa.
100 µg/$403
LECT1 / Chondromodulin-I Protein
Select
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
LECT1 / Chondromodulin-I Protein - 12.5% SDS-PAGE of human LECT1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
63.5 kDa
2 µg/$439
LECT1 / Chondromodulin-I Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
36.97 kDa
20 µg/$150
LECT1 / Chondromodulin-I Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
36.97 kDa
100 µg/$494
LECT1 / Chondromodulin-I Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
LECT1 / Chondromodulin-I Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
42.1 kDa
100 µg/$600
LECT1 / Chondromodulin-I Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
16.1 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 200 µg/$484
LECT1 / Chondromodulin-I Protein - Recombinant Leukocyte Cell Derived Chemotaxin 1 By SDS-PAGE
Select
E. coli
His-T7
26.8 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).