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Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
Gene Name: | lysocardiolipin acyltransferase 1 |
Synonyms: | LCLAT1, 1-AGPAT 8, 1AGPAT8, 1-AGP acyltransferase 8, ALCAT1, AGPAT8, LYCAT, HSRG1849, UNQ1849 |
Target Sequences: | NP_001002257.1 Q6UWP7 |
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