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LBR / Lamin B Receptor belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
Gene Name: | lamin B receptor |
Synonyms: | LBR, DHCR14B, Lamin B receptor, Lamin-B receptor, PHA, LMN2R |
Target Sequences: | NM_002296 NP_002287.2 Q14739 |
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