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LAT
linker for activation of T cells
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
| Gene Name: | linker for activation of T cells |
| Synonyms: | LAT, p36-38, Pp36, LAT1 |
| Target Sequences: | NM_014387 NP_055202.1 O43561 |
Publications (1)
1
Formation of a mast cell synapse: Fc epsilon RI membrane dynamics upon binding mobile or immobilized ligands on surfaces. Carroll-Portillo A, Spendier K, Pfeiffer J, Griffiths G, Li H, Lidke KA, Oliver JM, Lidke DS, Thomas JL, Wilson BS, Timlin JA. Journal of immunology (Baltimore, Md. : 1950). 2010 184:1328-38. (ICC)
[PubMed:20042583]
[PMC:PMC3087819]
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ELISA Kits
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Cell-Based Phosphorylation
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Primary
(88)
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(5)
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(12)
Sandwich CLIA
(2)
Target
LAT
(115)
Reactivity
Human
(88)
Mouse
(55)
Rat
(41)
Chicken
(1)
Guinea pig
(1)
Horse
(1)
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(1)
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(1)
Sheep
(1)
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(8)
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(5)
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(84)
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(9)
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rabbit
(74)
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(44)
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monoclonal mc
(12)
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(76)
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(1)
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(4)
LAT1111
(1)
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12 x 8-Well Microstrips
(2)
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(5)
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(13)
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(3)
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(5)
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(5)
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(1)
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(5)
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(57)
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aa25-221
(8)
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(8)
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(8)
pTyr171
(4)
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(4)
140-220 aa
(2)
160-240 aa
(2)
C-Terminus
(2)
Cytoplasmic Domain
(2)
aa31-233
(2)
pTyr255
(2)
60-140 aa
(1)
Asp156
(1)
Leu185
(1)
N-Terminus
(1)
Tyr191/Tyr220
(1)
aa107-156
(1)
aa171-220
(1)
aa191-240
(1)
aa201-262
(1)
aa258-269
(1)
aa28-233
(1)
aa30-113
(1)
aa70-120
(1)
aa86-135
(1)
p161
(1)
p171
(1)
p191
(1)
p255
(1)
pTyr132
(1)
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(1)
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(115)
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(3)
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(2)
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(6)
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(6)
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(4)
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(1)
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(2)
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Human
(4)
Mouse
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(1)
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293T Cells
(1)
E. coli
(4)
HEK 293 Cells
(1)
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(1)
Purification
Purified
(1)
LAT Rabbit anti-Human Polyclonal (aa70-120) Antibody
Mouse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$460
Cancer
LAT Mouse anti-Human Monoclonal (Cytoplasmic Domain) (LAT1111) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
LAT Rabbit anti-Human Polyclonal (aa31-233) Antibody
Mouse, Human
IP, WB
Unconjugated
100 µg/$483; 400 µg/$832
LAT Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Human
IP, WB
FITC Conjugated
100 µl/$1,027
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261; 20 µg/$298; 100 µg/$454; 500 µg/$1,177
LAT Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$556
LAT Rabbit anti-Human Polyclonal (pTyr191) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
LAT Goat anti-Human Polyclonal (aa258-269) Antibody
Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
![LAT Antibody - Immunoperoxidase of monoclonal antibody to LAT on formalin-fixed paraffin-embedded human tonsil tissue. [antibody concentration 5 ug/ml].](https://lsbio-7d62.kxcdn.com/image2/lat-antibody-clone-3b11-1d5-ls-c133721/52719_5011068.jpg)
LAT Mouse anti-Human Monoclonal (3B11-1D5) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
LAT Rabbit anti-Human Polyclonal (pTyr191) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
LAT Rabbit anti-Human Polyclonal (160-240 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LAT Mouse anti-Human Monoclonal (Cytoplasmic Domain) (LAT-01) Antibody
Human
Flo, IP, WB
Unconjugated
0.1 mg/$323
LAT Mouse anti-Human Monoclonal (LAT-01) Antibody
Human
Flo, IP, WB
Unconjugated
100 µg/$447
LAT Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
LAT Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
LAT Rabbit anti-Human Polyclonal (pTyr220) Antibody
Mouse, Rat, Human
ELISA, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
LAT Rabbit anti-Human Polyclonal (140-220 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LAT Rabbit anti-Human Polyclonal (60-140 aa) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LAT Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
LAT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LAT Mouse anti-Human Monoclonal (aa31-233) Antibody
Mouse, Human
IP, WB
Unconjugated
100 µg/$587
LAT Mouse anti-Human Monoclonal (Concentrated) (LAT-01) Antibody
Human
IP, WB
Unconjugated, Concentrated
0.1 mg/$508
LAT Rabbit anti-Human Polyclonal (140-220 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LAT Rabbit anti-Human Polyclonal (160-240 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
LAT Rabbit anti-Human Polyclonal (p171) Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
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