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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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LAMA3 / Laminin Alpha 3
laminin, alpha 3
LAMA3 / Laminin Alpha 3 belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants.
| Gene Name: | laminin, alpha 3 |
| Family/Subfamily: | Laminin , not assigned-Laminin |
| Synonyms: | LAMA3, BM600, Epiligrin 170 kDa subunit, E170, Kalinin-165kDa, Lama3a, Laminin Alpha 3, Laminin alpha-3 chain, Laminin-5 alpha 3 chain, Nicein-150kDa, Laminin, alpha 3, LOCS, Nicein 150kD subunit, BM600 150kD subunit, BM600-150kDa, Epiligrin, Epiligrin alpha 3 subunit, Epiligrin subunit alpha, Kalinin 165kD subunit, Kalinin subunit alpha, Laminin subunit alpha-3, Laminin-5 subunit alpha, Laminin-6 subunit alpha, Laminin-7 subunit alpha, LAMNA, Nicein subunit alpha |
| Target Sequences: | NM_000227 NP_000218.3 Q16787 |
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