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Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Gene Name: | L(3)mbt-like 1 (Drosophila) |
Synonyms: | L3MBTL1, DJ138B7.3, H-L(3)MBT, H-l(3)mbt protein, L(3)mbt-like, KIAA0681, ZC2HC3, L(3)mbt (Drosophila)-like, L(3)mbt protein homolog, L(3)mbt-like (Drosophila), L(3)mbt-like 1 (Drosophila), L3MBT, L3MBTL |
Target Sequences: | NM_032107 NP_115479.4 Q9Y468 |
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