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L1CAM

L1 cell adhesion molecule

L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

Gene Name: L1 cell adhesion molecule
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: L1CAM, CAML1, CD171 antigen, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, L1 cell adhesion molecule, NCAM-L1, S10, SPG1, CD171
Target Sequences: NP_000416.1 P32004

Publications (4)

1
An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage. Jae-Kyung Nam , A-Ram Kim , Seo-Hyun Choi , Ji-Hee Kim, Kyu Jin Choi, Seulki Cho, Jae Won Lee, Hyun-Jai Cho, Yoo-Wook Kwon, Jaeho Cho, Kwang Seok Kim, Joon Kim, Hae-June Lee, Tae Sup Lee, Sangwoo Bae, Hyo Jeong Hong, Yoon-Jin Lee. Nature communications. 2021 June;12:3279. [Full Text Article] [PubMed:34078883] [PMC:PMC8172563] Related Antibodies: LS-B9803.
2
Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats. Raghubendra Singh Dagur, Ke Liao, Susmita Sil, Fang Niu, Zhiqiang Sun, Yuri L Lyubchenko, Eric S Peeples, Guoku Hu, Shilpa Buch. Journal of Extracellular Vesicles. 2020 Dec;9:1703249. [Full Text Article] [PubMed:32002168] [PMC:PMC6968593] Related Antibodies: LS-C470565.
3
Preoperative Risk Stratification of Endometrial Carcinoma: L1CAM as a Biomarker. Annukka Pasanen, Mikko Loukovaara, Taru Tuomi, Ralf Bützow. The Breast : official journal of the European Society of Mastology. 2017 Sep;;27:1318-1324. [Full Text Article] [PubMed:29059097]
4
Glutamine Supplementation Preserves Glutamatergic Neuronal Activity in the Infralimbic Cortex, Which Delays the Onset of Mild Cognitive Impairment in 3×Tg-AD Female Mice. Ji Hyeong Baek, Jae Soon Kang, Miyoung Song, Dong Kun Lee, Hyun Joon Kim. Nutrients. 2023 June;15: [Full Text Article] [PubMed:37375700] [PMC:PMC10303714] Related Antibodies: LS-C685295.
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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
L1CAM (8)
No (8)
GST, N-terminus (1)
His (3)
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Human (6)
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293T Cells (1)
E. coli (3)
HEK 293 Cells (2)
Human Cells (1)
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Purified (1)
Low endotoxin level (1)
L1CAM Protein - Recombinant L1-Cell Adhesion Molecule By SDS-PAGE
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E. coli
His-GST
59.9 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
L1CAM Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
140 kDa
100 µg/$710
L1CAM Protein - Recombinant L1-Cell Adhesion Molecule By SDS-PAGE
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E. coli
His
20.0 kDa
10 µg/$249; 50 µg/$307; 100 µg/$385; 200 µg/$482; 1 mg/$1,325; 500 µg/$962; 5 mg/$2,204; 2 mg/$1,480
L1CAM Protein - Purified recombinant protein L1CAM was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
137.8 kDa
20 µg/$1,107
L1CAM Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
125 kDa
100 µg/$793; 1 mg/$4,191
L1CAM Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
140 kDa
20 µg/$215
L1CAM Protein - Recombinant L1-Cell Adhesion Molecule By SDS-PAGE
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E. coli
His
24.8 kDa
10 µg/$249; 50 µg/$307; 100 µg/$385; 200 µg/$482; 1 mg/$1,325; 500 µg/$962; 5 mg/$2,204; 2 mg/$1,480
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).