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L1CAM
L1 cell adhesion molecule
L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
| Gene Name: | L1 cell adhesion molecule |
| Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
| Synonyms: | L1CAM, CAML1, CD171 antigen, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, L1 cell adhesion molecule, NCAM-L1, S10, SPG1, CD171 |
| Target Sequences: | NP_000416.1 P32004 |
Publications (4)
1
An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage. Jae-Kyung Nam , A-Ram Kim , Seo-Hyun Choi , Ji-Hee Kim, Kyu Jin Choi, Seulki Cho, Jae Won Lee, Hyun-Jai Cho, Yoo-Wook Kwon, Jaeho Cho, Kwang Seok Kim, Joon Kim, Hae-June Lee, Tae Sup Lee, Sangwoo Bae, Hyo Jeong Hong, Yoon-Jin Lee. Nature communications. 2021 June;12:3279. [Full Text Article]
[PubMed:34078883]
[PMC:PMC8172563]
Related Antibodies: LS-B9803.
2
Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats. Raghubendra Singh Dagur, Ke Liao, Susmita Sil, Fang Niu, Zhiqiang Sun, Yuri L Lyubchenko, Eric S Peeples, Guoku Hu, Shilpa Buch. Journal of Extracellular Vesicles. 2020 Dec;9:1703249. [Full Text Article]
[PubMed:32002168]
[PMC:PMC6968593]
Related Antibodies: LS-C470565.
3
Preoperative Risk Stratification of Endometrial Carcinoma: L1CAM as a Biomarker. Annukka Pasanen, Mikko Loukovaara, Taru Tuomi, Ralf Bützow. The Breast : official journal of the European Society of Mastology. 2017 Sep;;27:1318-1324. [Full Text Article]
[PubMed:29059097]
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(3)
L1CAM Rabbit anti-Human Polyclonal (aa1154-1182) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
Neuroscience
L1CAM Mouse anti-Human Monoclonal (UJ127.11) Antibody
Human
IHC, IHC-P
Unconjugated
0.1 mg/$460
L1CAM Mouse anti-Human Monoclonal (OTI2H5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI2H5) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
L1CAM Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
L1CAM Rabbit anti-Mouse Polyclonal (aa882-1132) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567; 2 ml/$769; 5 ml/$1,248
L1CAM Mouse anti-Human Monoclonal (OTI4F4) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI4F4) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Rabbit anti-Human Monoclonal (Preservative Free) (014) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P
Unconjugated, Preservative Free
20 µl/$286; 100 µl/$435
L1CAM Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$535
L1CAM Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Rat, Mouse, Human
ICC, IF, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
L1CAM Mouse anti-Human Monoclonal (OTI2H6) Antibody
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI2H6) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Mouse anti-Human Monoclonal (OTI2C7) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI2C7) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Mouse anti-Human Monoclonal (OTI2A6) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI2A6) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Mouse anti-Human Monoclonal (OTI3G1) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI3G1) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Rabbit anti-Human Polyclonal (aa1154-1182) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
L1CAM Mouse anti-Human Monoclonal (UMAB47) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
L1CAM Mouse anti-Human Monoclonal (Carrier-free) (UMAB47) Antibody
Human
IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
L1CAM Mouse anti-Human Monoclonal (Carrier-free) (OTI1H3) Antibody
Human
Flo, IF, IP, WB
Unconjugated, Carrier-free
100 µg/$511
L1CAM Mouse anti-Human Monoclonal (OTI10C12) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
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