KSR2

kinase suppressor of Ras 2

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

KSR2 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human KSR2 Protein (Recombinant GST, N-terminus) (aa411-500) - LS-G63878

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human KSR2 Protein (Recombinant GST) (Full Length) - LS-G37195

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

120 kDa

Price:

2 µg/$439

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Human KSR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92693

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

104.1 kDa

Price:

20 µg/$215

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KSR2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105235

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

104.1 kDa

Price:

100 µg/$710

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