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The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.
Gene Name: | keratin 81 |
Family/Subfamily: | Keratin , not assigned-Keratin |
Synonyms: | KRT81, GhHkb1, Hard keratin, type II, 1, HB1, Hair keratin K2.9, HB-1, Keratin, type ii hair-specific, K81, Keratin 81, Keratin, hair, basic, 1, GhHb1, MLN137, HHAKB2-1, Keratin, type II cuticular Hb1, Keratin-81, MLN 137, Type II hair keratin Hb1, Type-II keratin Kb21, KRTHB1 |
Target Sequences: | NM_002281 NP_002272.2 Q14533 |
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