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KRT6A / CK6A / Cytokeratin 6A

keratin 6A

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Gene Name: keratin 6A
Family/Subfamily: Keratin , not assigned-Keratin
Synonyms: KRT6A, Allergen Hom s 5, CK6A, CK-6D, CK6C, Cytokeratin 6C, Cytokeratin-6A, Cytokeratin-6D, CK-6A, Cytokeratin 6A, K6D, Keratin 6 isoform k6d, Keratin 6D, Keratin-6A, Type-II keratin Kb6, CK6D, Cytokeratin 6D, K6A, K6C, Keratin 6 isoform k6a, Keratin 6A, Keratin 6C, KRT6D
Target Sequences: NM_005554 NP_005545.1 P02538

Publications (1)

1
Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells. Chang Liu, Tiffany Tate, Ekatherina Batourina, Steven T Truschel, Steven Potter, Mike Adam, Tina Xiang, Martin Picard, Maia Reiley, Kerry Schneider, Manuel Tamargo, Chao Lu, Xiao Chen, Jing He, Hyunwoo Kim, Cathy Lee Mendelsohn. Nature communications. 2019 Oct;10:4589. [Full Text Article] [PubMed:31597917] [PMC:PMC6785552] Related Antibodies: LS-B12036.

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KRT6A / CK6A / Cytokeratin 6A (6)
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KRT6A / CK6A / Cytokeratin 6A ELISA Kit
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96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$579
KRT6A / CK6A / Cytokeratin 6A ELISA Kit
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78 - 5000 pg/ml
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1 Plate/$669
KRT6A / CK6A / Cytokeratin 6A ELISA Kit
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Human
15.63 - 1000 pg/ml
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KRT6A / CK6A / Cytokeratin 6A ELISA Kit
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Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
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1 Plate/$669
KRT6A / CK6A / Cytokeratin 6A ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
KRT6A / CK6A / Cytokeratin 6A ELISA Kit
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Sandwich
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Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$897
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).