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KRT17 / CK17 / Cytokeratin 17

keratin 17

May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.

Gene Name: keratin 17
Family/Subfamily: Keratin , not assigned-Keratin
Synonyms: KRT17, 39.1, Cytokeratin 17, Cytokeratin-17, K17, Keratin 17 epitope S2, Keratin 17 epitope S4, Keratin 17, PC2, PCHC1, CK-17, Keratin 17 epitope S1, Keratin-17
Target Sequences: NM_000422 NP_000413.1 Q04695

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Proteins (6)
Recombinant (6)
KRT17 / CK17 / Cytokeratin 17 (6)
No (6)
6His, N-terminus (1)
GST (1)
His (2)
His-S (1)
His-SUMO (1)
Bovine (1)
Human (4)
Rat (1)
E. coli (5)
Wheat Germ Extract (1)
Purified (2)
KRT17 / CK17 / Cytokeratin 17 Protein
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E. coli
6His, N-terminus
50 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
KRT17 / CK17 / Cytokeratin 17 Protein - 12.5% SDS-PAGE of human KRT17 stained with Coomassie Blue
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Wheat Germ Extract
GST
73.26 kDa
10 µg/$479; 25 µg/$670
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E. coli
His-SUMO
64.71 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
KRT17 / CK17 / Cytokeratin 17 Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
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E. coli
His-S
22.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
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E. coli
His
37.1 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).