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KRAS

Kirsten rat sarcoma viral oncogene homolog

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. Mutations in this gene are associated with leukemia, lung, breast, bladder, pancreatic, and stomach cancer.

Gene Name: Kirsten rat sarcoma viral oncogene homolog
Family/Subfamily: Ras GTPase superfamily IPR001806 , RAS oncogene
Synonyms: KRAS, C-K-RAS, C-Ki-ras, C-Kirsten-ras protein, GTPase KRas, K-ras p21 protein, K-RAS2B, K-RAS2, KRAS2, NS, NS3, K-RAS4A, KRAS1, RASK2, Transforming protein p21, Oncogene KRAS2, K-Ras 2, K-RAS2A, K-RAS4B, KI-RAS, PR310 c-K-ras oncogene
Target Sequences: NM_004985 NP_203524.1 P01116

Publications (2)

1
Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange. Guillard S, Kolasinska-Zwierz P, Debreczeni J, Breed J, Zhang J, Bery N, Marwood R, Tart J, Overman R, Stocki P, Mistry B, Phillips C, Rabbitts T, Jackson R, Minter R. Nature communications. 2017 July;8:16111. (Human) [Full Text Article] [PubMed:28706291] [PMC:PMC5519984] Related Antibodies: LS-C175665.
2
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling. Alexander N Kapustin, Paul Davey, David Longmire, Carl Matthews, Emily Linnane, Nitin Rustogi, Maria Stavrou, Paul W A Devine, Nicholas J Bond, Lyndsey Hanson, Silvia Sonzini, Alexey Revenko, A Robert MacLeod, Sarah Ross, Elisabetta Chiarparin, Sanyogitta Puri. Communications biology. 2021 Nov;4:1241. [Full Text Article] [PubMed:34725463] [PMC:PMC8560811] Related Antibodies: LS-C175665.

☰ Filters
Antibodies (75)
Proteins (20)
ELISA Kits (3)
Over-Expression Lysate (4)
Primary (75)
Recombinant (16)
Sandwich (3)
KRAS (98)
Human (66)
Mouse (23)
Rat (25)
Bat (6)
Bovine (6)
Chicken (6)
Chimpanzee (3)
Dog (6)
Drosophila (3)
Gibbon (6)
Guinea pig (6)
Hamster (3)
Horse (6)
Monkey (3)
Orangutan (3)
Pig (14)
Rabbit (6)
Xenopus (6)
Zebrafish (6)
IHC (12)
IHC-P (12)
WB (67)
Flo (5)
ELISA (16)
ICC (2)
IF (10)
IP (2)
Peptide-ELISA (1)
rabbit (51)
mouse (24)
Product Group
IHCPlus (3)
PathPlus Cancer (1)
PathPlus Cancer Pathology (1)
IgG (27)
IgG1 (19)
IgG1,k (1)
IgG2b (4)
monoclonal mc (24)
polyclonal pc (51)
2C1 (2)
3B10-2F2 (1)
9.13 (1)
OTI1D1 (2)
OTI2F8 (2)
OTI2G6 (2)
OTI3B12 (2)
OTI4B3 (2)
OTI4C6 (2)
OTI4F6 (2)
OTI5H6 (2)
OTI6A6 (2)
OTI8B4 (2)
96-Well Strip Plate (3)
APC (1)
APC Conjugated (3)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 594 Conjugated (1)
Biotin Conjugated (7)
Carrier-free (11)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (7)
HRP Conjugated (6)
PE Conjugated (2)
PerCP Conjugated (1)
Unconjugated (44)
aa1-189 (9)
aa146-174 (6)
N-Terminus (4)
aa61-110 (4)
C-Terminus (2)
aa2-168 (2)
Internal (1)
aa150-200 (1)
aa159-184 (1)
No (97)
Yes (1)
Cell Culture Supernatants (1)
Cell Lysates (1)
Plasma (3)
Serum (3)
Tissue Homogenates (2)
6His, N-terminus (6)
GST (1)
GST, N-terminus (1)
His (4)
His-T7 (1)
Myc-DDK (Flag) (6)
Myc-DDK (Flag), C-terminus (1)
Human (18)
293T Cells (2)
E. coli (11)
HEK 293 Cells (5)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (6)
KRAS Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
Fast Shipping
KRAS Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
KRAS Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KRAS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KRAS.
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KRAS Mouse anti-Human Monoclonal (2C1) Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$450
KRAS Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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KRAS Mouse anti-Human Monoclonal (Carrier-free) (2C1) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
KRAS Antibody - Anti-KRAS antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KRAS Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
KRAS Antibody - IHC (P) of K-Ras Antibody (9.13) showing staining in the cytoplasm and membrane of paraffin-embedded human prostate carcinoma (right) compared to a negative control without primary antibody (left).
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KRAS Mouse anti-Human Monoclonal (C-Terminus) (9.13) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100 µg/$504
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KRAS Rabbit anti-Human Polyclonal (aa146-174) Antibody
Mouse, Human
ELISA, Flo, IF, WB
Unconjugated
200 µl/$734
Select
KRAS Rabbit anti-Human Polyclonal (aa146-174) (Biotin) Antibody
Mouse, Human
ELISA, Flo, IF, WB
Biotin Conjugated
200 µl/$952
Select
KRAS Rabbit anti-Human Polyclonal (aa146-174) (PE) Antibody
Mouse, Rat, Human
ELISA, Flo, ICC, IF, WB
PE Conjugated
200 µl/$952
Select
KRAS Rabbit anti-Human Polyclonal (aa146-174) (APC) Antibody
Mouse, Human
ELISA, Flo, ICC, IF, WB
APC Conjugated
200 µl/$952
KRAS Antibody - Western blot analysis of extracts of SW480 cell line, using KRAS antibody.
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KRAS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
KRAS Antibody - Anti-KRAS antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KRAS Rabbit anti-Human Polyclonal (aa2-168) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
KRAS Antibody - Anti-KRAS antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KRAS Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
50 µg/$294; 100 µg/$360
KRAS ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$730
KRAS Protein - 12.5% SDS-PAGE of human KRAS stained with Coomassie Blue
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Wheat Germ Extract
GST
46.42 kDa
10 µg/$479; 25 µg/$670
KRAS ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
KRAS ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
23.5 - 1500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
KRAS Antibody - Immunofluorescence of monoclonal antibody to KRAS on HeLa cell. [antibody concentration 10 ug/ml]
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KRAS Mouse anti-Human Monoclonal (3B10-2F2) Antibody
Human
IF, WB
Unconjugated
100 µg/$423
KRAS Antibody - Human Colon Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
KRAS Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
KRAS Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KRAS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KRAS.
Select
KRAS Mouse anti-Human Monoclonal (OTI5H6) Antibody
Human
WB
Unconjugated
100 µl/$434
KRAS Protein - Recombinant Human KRAS(G12C, N-6His)
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
23.6 kDa
10 µg/$258; 50 µg/$352
KRAS Antibody
Select
KRAS Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$332
KRAS Antibody - Immunohistochemistry of paraffin-embedded human colon cancer at dilution of 1:100
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KRAS Rabbit anti-Human Polyclonal (aa2-168) Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
KRAS Protein - Purified recombinant protein KRAS was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
21.2 kDa
20 µg/$1,107
KRAS Protein
Select
E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
Select
KRAS Rabbit anti-Human Polyclonal (aa1-189) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
Viewing 1-25 of 98 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).