KPNA2 / Importin Alpha 1

karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination.

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ELISA Kits (6)

Type

Custom (2)

Development Kit (1)

Sandwich (3)

Target

KPNA2 / Importin Alpha 1 (6)

Reactivity

Human (5)

Mouse (1)

Product Group

DevKit DuoPlus (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (4)

Antibody Pair and Standard (1)

Publications

No (6)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (2)

Plasma (2)

Serum (2)

Tissue Homogenates (3)

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Human KPNA2 / Importin Alpha 1 (Sandwich ELISA) ELISA Kit - LS-F8290

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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Human KPNA2 / Importin Alpha 1 (Sandwich ELISA) ELISA Kit - LS-F33089

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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DevKit DuoPlus Human KPNA2 / Importin Alpha 1 ELISA Development Kit - LS-F71513

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

250 - 16000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,120; 1000 Wells/$1,642

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Human KPNA2 / Importin Alpha 1 (Custom ELISA) ELISA Kit - LS-F16148

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Mouse KPNA2 / Importin Alpha 1 (Custom ELISA) ELISA Kit - LS-F16149

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human KPNA2 / Importin Alpha 1 (Sandwich ELISA) ELISA Kit - LS-F50096

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

2 - 500 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$610

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