KPNA1 / Importin Alpha 5

karyopherin alpha 1 (importin alpha 5)

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

KPNA1 / Importin Alpha 5 (6)

Publications

No (6)

Tag

6His, N-terminus (2)

GST (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human KPNA1 / Importin Alpha 5 Protein (Recombinant 6His, N-terminus) (aa239-506) - LS-G15528

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

33.3 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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Human KPNA1 / Importin Alpha 5 Protein (Recombinant GST) (Full Length) - LS-G29136

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

84.92 kDa

Price:

10 µg/$479; 25 µg/$670

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Human KPNA1 / Importin Alpha 5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66012

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$1,107

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KPNA1 / Importin Alpha 5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99712

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

100 µg/$494

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Human KPNA1 / Importin Alpha 5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76750

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$150

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Human KPNA1 / Importin Alpha 5 Protein (Recombinant 6His, N-terminus) (aa8-538) - LS-G64205

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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