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Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined.
Gene Name: | killer cell lectin-like receptor subfamily G, member 1 |
Synonyms: | KLRG1, 2F1, CLEC15A, MAFA-2F1, MAFA-L, MAFA-LIKE, MAFA-like receptor, MAFAL |
Target Sequences: | NM_005810 NP_005801.3 Q96E93 |
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