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KLK7 / Kallikrein 7 is a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19.
Gene Name: | kallikrein-related peptidase 7 |
Family/Subfamily: | Protease , Serine S1 |
Synonyms: | KLK7, HK7, Kallikrein-related peptidase 7, HSCCE, Kallikrein 7, Kallikrein-7, PRSS6, Serine protease 6, SCCE, Signal protein |
Target Sequences: | NM_005046 NP_005037.1 P49862 |
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