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KLK4 / Kallikrein 4

kallikrein-related peptidase 4

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene.

Gene Name: kallikrein-related peptidase 4
Family/Subfamily: Protease , Serine S1
Synonyms: KLK4, AI2A1, ARM1, Androgen-regulated message 1, EMSP, EMSP1, Kallikrein-like protein 1, Kallikrein, Prostase, PRSS17, PSTS, Kallikrein 4, Kallikrein-4, Kallikrein-related peptidase 4, KLK-L1, Serine protease 17
Target Sequences: NM_004917 NP_004908.4 Q9Y5K2

Publications (1)

1
Full Spectrum of Postnatal Tooth Phenotypes in a Novel Irf6 Cleft Lip Model. Chu EY, Tamasas B, Fong H, Foster BL, LaCourse MR, Tran AB, Martin JF, Schutte BC, Somerman MJ, Cox TC. Journal of dental research. 2016 October;95:1265-73. (Human) [Full Text Article] [PubMed:27369589] [PMC:PMC5076757]

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Products
Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
KLK4 / Kallikrein 4 (8)
No (8)
6His, C-terminus (2)
GST (1)
His, N-Terminal (1)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (5)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
KLK4 / Kallikrein 4 Protein - Recombinant Kallikrein 4 By SDS-PAGE
Select
E. coli
His, N-Terminal
28.1 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
KLK4 / Kallikrein 4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.03 kDa
20 µg/$150
KLK4 / Kallikrein 4 Protein - Recombinant  Kallikrein 4 By SDS-PAGE
Select
E. coli
His-T7
28.4 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
KLK4 / Kallikrein 4 Protein - 12.5% SDS-PAGE of human KLK4 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
53.4 kDa
10 µg/$479; 25 µg/$670
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.44kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
KLK4 / Kallikrein 4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
27.03 kDa
100 µg/$494
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.4 kDa
10 µg/$317
KLK4 / Kallikrein 4 Protein - Recombinant Kallikrein 4 By SDS-PAGE
Select
E. coli
His-GST
56.2 kDa
10 µg/$283; 50 µg/$457; 100 µg/$732; 200 µg/$912; 1 mg/$2,032; 500 µg/$1,567; 5 mg/$3,193; 2 mg/$2,219
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).