KLHL25

kelch-like family member 25

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

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Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

KLHL25 (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human KLHL25 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86814

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$150

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KLHL25 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110334

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

100 µg/$494

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Human KLHL25 Protein (Recombinant GST) (Full Length) - LS-G34989

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

90.64 kDa

Price:

10 µg/$479; 25 µg/$670

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