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KLHL12
kelch-like family member 12
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
| Gene Name: | kelch-like family member 12 |
| Synonyms: | KLHL12, C3IP1, DKIR, HDKIR, Kelch-like 12 (Drosophila), Kelch-like protein C3IP1, Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog |
| Target Sequences: | NM_021633 NP_067646.1 Q53G59 |
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