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KLHL12
kelch-like family member 12
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.
| Gene Name: | kelch-like family member 12 |
| Synonyms: | KLHL12, C3IP1, DKIR, HDKIR, Kelch-like 12 (Drosophila), Kelch-like protein C3IP1, Kelch-like protein 12, CUL3-interacting protein 1, DKIR homolog |
| Target Sequences: | NM_021633 NP_067646.1 Q53G59 |
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KLHL12
(39)
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(34)
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(4)
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(39)
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(1)
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(1)
KLHL12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (OTI4E1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (Carrier-free) (OTI4E1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
KLHL12 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
KLHL12 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC
HRP Conjugated
50 µg/$294; 100 µg/$360
KLHL12 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
50 µg/$294; 100 µg/$360
KLHL12 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC
FITC Conjugated
50 µg/$294; 100 µg/$360
KLHL12 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
KLHL12 Mouse anti-Human Monoclonal (2G2) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$435
KLHL12 Rabbit anti-Human Polyclonal (aa376-404) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
KLHL12 Rabbit anti-Human Polyclonal (aa376-404) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
KLHL12 Rabbit anti-Human Polyclonal (aa376-404) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
KLHL12 Rabbit anti-Human Polyclonal (aa376-404) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
KLHL12 Rabbit anti-Human Polyclonal (aa376-404) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
KLHL12 Rabbit anti-Human Polyclonal (aa376-404) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (OTI4C10) Antibody
Human
WB
Unconjugated
100 µl/$434
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (Carrier-free) (OTI4C10) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (OTI1D2) Antibody
Human
WB
Unconjugated
100 µl/$434
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (Carrier-free) (OTI1D2) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (OTI1E6) Antibody
Human
WB
Unconjugated
100 µl/$434
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (Carrier-free) (OTI1E6) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (OTI5C12) Antibody
Human
WB
Unconjugated
100 µl/$434
KLHL12 Mouse anti-Human Monoclonal (aa177-405) (Carrier-free) (OTI5C12) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
KLHL12 Mouse anti-Human Monoclonal (2G2) Antibody
Human
WB
Unconjugated
100 µl/$518
KLHL12 Rabbit anti-Human Polyclonal (aa68-117) Antibody
Human
WB
Unconjugated
100 µl/$424
Viewing 1-25
of 39
product results
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