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KLF8 is a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.
Gene Name: | Kruppel-like factor 8 |
Synonyms: | KLF8, Basic kruppel-like factor 3, BKLF3, DXS741, Krueppel-like factor 8, Kruppel-like factor 8, Zinc finger protein 741, Basic krueppel-like factor 3, ZNF741 |
Target Sequences: | NM_007250 NP_009181.2 O95600 |
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