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KLF5 / BTEB2 is a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants.
Gene Name: | Kruppel-like factor 5 (intestinal) |
Synonyms: | KLF5, BTE-binding protein 2, BTEB2, Colon kruppel-like factor, Colon krueppel-like factor, GC box binding protein 2, IKLF, Gc box-binding protein bteb2, GC-box-binding protein 2, Transcription factor BTEB2, Krueppel-like factor 5 |
Target Sequences: | NM_001730 NP_001721.2 Q13887 |
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