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Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
Gene Name: | Kruppel-like factor 11 |
Synonyms: | KLF11, FKLF1, Krueppel-like factor 11, Kruppel-like factor 11, Tieg3, MODY7, TIEG2, TIEG-2, FKLF |
Target Sequences: | NM_003597 NP_003588.1 O14901 |
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