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KITLG / SCF
KIT ligand
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
| Gene Name: | KIT ligand |
| Synonyms: | KITLG, C-Kit ligand, KIT ligand, Kitl, KL-1, SHEP7, SF, Steel factor, Stem cell factor, SCF, FPH2, Mast cell growth factor, MGF |
| Target Sequences: | NM_000899 NP_000890.1 P21583 |
Publications (2)
1
The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour. Fukuzawa R, , Anaka MR, Morison IM, Reeve AE. PloS one. 2017 12:e0186333. (ICC, WB; Human)
[Full Text Article]
[PubMed:29040332]
Related Antibodies: LS-B5002.
2
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Nicolas Severe, Nezihi Murat Karabacak, Karin Gustafsson, Ninib Baryawno, Gabriel Courties, Youmna Kfoury, Konstantinos D Kokkaliaris, Catherine Rhee, Dongjun Lee, Elizabeth W Scadden, Juan Esteban Garcia-Robledo, Thomas Brouse, Matthias Nahrendorf, Mehmet Toner, David T Scadden. Cell stem cell. 2019 October;25:570-583.e7. [Full Text Article]
[PubMed:31279774]
[PMC:PMC6778015]
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(66)
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(66)
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KITLG / SCF
(66)
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(40)
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(55)
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(9)
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(8)
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(1)
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(1)
Publications
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(65)
Yes
(1)
KITLG / SCF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
KITLG / SCF Rabbit anti-Human Polyclonal (aa180-229) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
KITLG / SCF Rabbit anti-Human Polyclonal (aa180-229) (HRP) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Goat, Dog, Rat, Hamster, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
KITLG / SCF Rabbit anti-Human Polyclonal (aa180-229) (Biotin) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Goat, Dog, Rat, Hamster, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
KITLG / SCF Rabbit anti-Human Polyclonal (aa180-229) (FITC) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Goat, Dog, Rat, Hamster, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
KITLG / SCF Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
KITLG / SCF Mouse anti-Human Monoclonal (3E10) Antibody
Human
ELISA
Unconjugated
100 µg/$423
KITLG / SCF Rabbit anti-Mouse Polyclonal Antibody
Mouse
Inhb
Unconjugated
50 µg/$397; 100 µg/$449
KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) Antibody
Human
Flo, IF, WB
Unconjugated
400 µl/$393
KITLG / SCF Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
KITLG / SCF Mouse anti-Human Monoclonal (hKL12) Antibody
Human
IHC, IHC-P
Unconjugated
200 µg/$783
KITLG / SCF Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
KITLG / SCF Rabbit anti-Mouse Polyclonal (aa24-247) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$295; 200 µl/$331; 500 µl/$450; 1 ml/$510; 2 ml/$646; 5 ml/$1,098
KITLG / SCF Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
KITLG / SCF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
200 µl/$734
KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (Biotin) Antibody
Human
ELISA, Flo, IF, WB
Biotin Conjugated
200 µl/$952
KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, WB
FITC Conjugated
200 µl/$952
KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (APC) Antibody
Human
ELISA, Flo, ICC, IF, WB
APC Conjugated
200 µl/$952
KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (PE) Antibody
Human
ELISA, Flo, ICC, IF, WB
PE Conjugated
200 µl/$952
KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, WB
HRP Conjugated, Azide-free
200 µl/$952
KITLG / SCF Mouse anti-Human Monoclonal (OTI5F6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
KITLG / SCF Mouse anti-Human Monoclonal (Carrier-free) (OTI5F6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
KITLG / SCF Rabbit anti-Human Polyclonal (aa26-44) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
KITLG / SCF Mouse anti-Human Monoclonal (OTI6E5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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of 66
product results
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