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KITLG / SCF

KIT ligand

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Gene Name: KIT ligand
Synonyms: KITLG, C-Kit ligand, KIT ligand, Kitl, KL-1, SHEP7, SF, Steel factor, Stem cell factor, SCF, FPH2, Mast cell growth factor, MGF
Target Sequences: NM_000899 NP_000890.1 P21583

Publications (2)

1
The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour. Fukuzawa R, , Anaka MR, Morison IM, Reeve AE. PloS one. 2017 12:e0186333. (ICC, WB; Human) [Full Text Article] [PubMed:29040332] Related Antibodies: LS-B5002.
2
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Nicolas Severe, Nezihi Murat Karabacak, Karin Gustafsson, Ninib Baryawno, Gabriel Courties, Youmna Kfoury, Konstantinos D Kokkaliaris, Catherine Rhee, Dongjun Lee, Elizabeth W Scadden, Juan Esteban Garcia-Robledo, Thomas Brouse, Matthias Nahrendorf, Mehmet Toner, David T Scadden. Cell stem cell. 2019 October;25:570-583.e7. [Full Text Article] [PubMed:31279774] [PMC:PMC6778015]

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KITLG / SCF Antibody - Anti-KITLG / SCF antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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KITLG / SCF Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
KITLG / SCF Antibody - Anti-KITLG / SCF antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KITLG / SCF Rabbit anti-Human Polyclonal (aa180-229) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
KITLG / SCF Antibody - Anti-Human SCF Western Blot Unreduced
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KITLG / SCF Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
500 µg/$326
KITLG / SCF ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
KITLG / SCF Antibody - Detection limit for recombinant GST tagged KITLG is approximately 0.1 ng/ml as a capture antibody.
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KITLG / SCF Mouse anti-Human Monoclonal (3E10) Antibody
Human
ELISA
Unconjugated
100 µg/$423
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KITLG / SCF Rabbit anti-Mouse Polyclonal Antibody
Mouse
Inhb
Unconjugated
50 µg/$397; 100 µg/$449
KITLG / SCF ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
KITLG / SCF Antibody - Immunofluorescence of anti-KITLG Antibody in HeLa cells. 0.025 mg/ml primary antibody was followed by Alexa-Fluor-546-conjugated donkey anti-rabbit lgG (H+L). Alexa-Fluor-546 emits orange fluorescence. Blue counterstaining is DAPI.
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KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) Antibody
Human
Flo, IF, WB
Unconjugated
400 µl/$393
KITLG / SCF Antibody - Western Blot (non-reducing) of SCF antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KITLG / SCF Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
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KITLG / SCF Mouse anti-Human Monoclonal (hKL12) Antibody
Human
IHC, IHC-P
Unconjugated
200 µg/$783
KITLG / SCF Antibody - Western Blot (non-reducing) of SCF antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KITLG / SCF Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
25 µg/$356; 50 µg/$396
KITLG / SCF Antibody - Western blot of recombinant KITLG / SCF.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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KITLG / SCF Rabbit anti-Mouse Polyclonal (aa24-247) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$295; 200 µl/$331; 500 µl/$450; 1 ml/$510; 2 ml/$646; 5 ml/$1,098
KITLG / SCF Antibody - Anti-SCF antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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KITLG / SCF Goat anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
KITLG / SCF Antibody - Immunohistochemistry - Anti-SCF Picoband Antibody
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KITLG / SCF Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
200 µl/$734
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KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (Biotin) Antibody
Human
ELISA, Flo, IF, WB
Biotin Conjugated
200 µl/$952
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KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, WB
FITC Conjugated
200 µl/$952
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KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (APC) Antibody
Human
ELISA, Flo, ICC, IF, WB
APC Conjugated
200 µl/$952
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KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (PE) Antibody
Human
ELISA, Flo, ICC, IF, WB
PE Conjugated
200 µl/$952
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KITLG / SCF Rabbit anti-Human Polyclonal (aa244-273) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, WB
HRP Conjugated, Azide-free
200 µl/$952
KITLG / SCF Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-KITLG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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KITLG / SCF Mouse anti-Human Monoclonal (OTI5F6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
KITLG / SCF ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Rat
16 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$414
KITLG / SCF ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
2.743 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
KITLG / SCF ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Rat
7.813 - 500 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
KITLG / SCF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
18.4 kDa
50 µg/$391; 10 µg/$294; 1 mg/$2,269; 500 µg/$1,540
Viewing 1-25 of 176 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).