KIR2DS2 / CD158j

Killer Cell Immunoglobulin-like Receptor, Two Domains, Short Cytoplasmic Tail, 2

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

KIR2DS2 / CD158j (4)

Publications

No (4)

Tag

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

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Human KIR2DS2 / CD158j Protein (Recombinant His-GST) (aa22-304) - LS-G15342

Source:

E. coli

Tag:

His-GST

Molecular Weight:

62.9 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Human KIR2DS2 / CD158j Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87938

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.5 kDa

Price:

20 µg/$150

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Human KIR2DS2 / CD158j Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70760

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

31.5 kDa

Price:

20 µg/$1,107

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KIR2DS2 / CD158j Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114499

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.5 kDa

Price:

100 µg/$494

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