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Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
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KIR2DS2 / CD158j
Killer Cell Immunoglobulin-like Receptor, Two Domains, Short Cytoplasmic Tail, 2
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants.
| Gene Name: | Killer Cell Immunoglobulin-like Receptor, Two Domains, Short Cytoplasmic Tail, 2 |
| Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
| Synonyms: | KIR2DS2, 1060P11.9.2, 183ActI, CD158j antigen, CD158J, Killer-cell Ig-like receptor, MHC class I NK cell receptor, NK receptor 183 ActI, p58 KIR, p58 NK receptor CL-49, Cl-49, NKAT-5, NKAT5 |
| Target Sequences: | NM_012312 NP_036444.1 P43631 |
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