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Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Gene Name: | lysine (K)-specific demethylase 5C |
Synonyms: | KDM5C, DXS1272E, MRXJ, MRXSCJ, MRXSJ, Histone demethylase JARID1C, Protein SmcX, Protein Xe169, SMCX, Smcy homolog, X-linked, Smcy homolog, X-linked (mouse), Lysine-specific demethylase 5C, XE169, Xe169 protein, JARID1C, Selected cDNA on X, Smcx homolog, X chromosome |
Target Sequences: | NM_004187 NP_004178.2 P41229 |
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