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Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Gene Name: | lysine (K)-specific demethylase 5B |
Synonyms: | KDM5B, CT31, JARID1B, Histone demethylase JARID1B, RBBP2H1A, Lysine-specific demethylase 5B, PUT1, RBP2-H1, Cancer/testis antigen 31, PLU-1, PLU1, RBBP2H1 |
Target Sequences: | NM_006618 NP_006609.3 Q9UGL1 |
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