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Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
Gene Name: | lysine (K)-specific demethylase 3A |
Synonyms: | KDM3A, JHDM2A, JMJD1A, Jumonji domain containing 1A, JHMD2A, JMJD1, KIAA0742, Jumonji domain containing 1, Testis-specific protein A, Lysine-specific demethylase 3A, TSGA |
Target Sequences: | NM_018433 NP_060903.2 Q9Y4C1 |
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