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Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
Gene Name: | potassium channel tetramerization domain containing 13 |
Family/Subfamily: | Ion Channel |
Synonyms: | KCTD13, BACURD1, FKSG86, HBACURD1, POLDIP1, PDIP1, TNFAIP1-like protein |
Target Sequences: | NM_178863 NP_849194.1 Q8WZ19 |
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